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Maximum postoperative delirium severity vs a) number of instrumented vertebral levels and vs postoperative concentrations of b) IL-8; c) IL-10; d) TNFα; e) IL-6; and f) <t>S100B.</t> TXA data points are shown in purple circles and lines and Placebo data points are shown in blue circles and lines. In panel a) TXA (n=32) and Placebo (n=33). In panels b-f) TXA (n=16) and Placebo (n=16). Robust regression lines are shown.
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Maximum postoperative delirium severity vs a) number of instrumented vertebral levels and vs postoperative concentrations of b) IL-8; c) IL-10; d) TNFα; e) IL-6; and f) <t>S100B.</t> TXA data points are shown in purple circles and lines and Placebo data points are shown in blue circles and lines. In panel a) TXA (n=32) and Placebo (n=33). In panels b-f) TXA (n=16) and Placebo (n=16). Robust regression lines are shown.
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Maximum postoperative delirium severity vs a) number of instrumented vertebral levels and vs postoperative concentrations of b) IL-8; c) IL-10; d) TNFα; e) IL-6; and f) <t>S100B.</t> TXA data points are shown in purple circles and lines and Placebo data points are shown in blue circles and lines. In panel a) TXA (n=32) and Placebo (n=33). In panels b-f) TXA (n=16) and Placebo (n=16). Robust regression lines are shown.
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Maximum postoperative delirium severity vs a) number of instrumented vertebral levels and vs postoperative concentrations of b) IL-8; c) IL-10; d) TNFα; e) IL-6; and f) <t>S100B.</t> TXA data points are shown in purple circles and lines and Placebo data points are shown in blue circles and lines. In panel a) TXA (n=32) and Placebo (n=33). In panels b-f) TXA (n=16) and Placebo (n=16). Robust regression lines are shown.
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Maximum postoperative delirium severity vs a) number of instrumented vertebral levels and vs postoperative concentrations of b) IL-8; c) IL-10; d) TNFα; e) IL-6; and f) <t>S100B.</t> TXA data points are shown in purple circles and lines and Placebo data points are shown in blue circles and lines. In panel a) TXA (n=32) and Placebo (n=33). In panels b-f) TXA (n=16) and Placebo (n=16). Robust regression lines are shown.
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Figure 5. BDNF, NSE, and <t>S100B</t> immunoreactivity in the hippocampuses and PBMCs of patients with MTLE; scale bar: 50 µm.
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Figure 5. BDNF, NSE, and <t>S100B</t> immunoreactivity in the hippocampuses and PBMCs of patients with MTLE; scale bar: 50 µm.
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Maximum postoperative delirium severity vs a) number of instrumented vertebral levels and vs postoperative concentrations of b) IL-8; c) IL-10; d) TNFα; e) IL-6; and f) S100B. TXA data points are shown in purple circles and lines and Placebo data points are shown in blue circles and lines. In panel a) TXA (n=32) and Placebo (n=33). In panels b-f) TXA (n=16) and Placebo (n=16). Robust regression lines are shown.

Journal: medRxiv

Article Title: Exploratory Randomised Trial of Tranexamic Acid to Decrease Postoperative Delirium in Adults Undergoing Lumbar Fusion: A trial stopped early

doi: 10.1101/2024.10.16.24315638

Figure Lengend Snippet: Maximum postoperative delirium severity vs a) number of instrumented vertebral levels and vs postoperative concentrations of b) IL-8; c) IL-10; d) TNFα; e) IL-6; and f) S100B. TXA data points are shown in purple circles and lines and Placebo data points are shown in blue circles and lines. In panel a) TXA (n=32) and Placebo (n=33). In panels b-f) TXA (n=16) and Placebo (n=16). Robust regression lines are shown.

Article Snippet: As a measure of neuroinflammation (astrocyte activation), plasma was analyzed for S100B protein using the Human S100B DuoSet enzyme linked immunosorbent assay (R&D Systems, Minneapolis, MN) following the manufacturer’s instructions (The lower limits of detection of each assay are reported in ).

Techniques:

Postoperative S100B concentration vs. postoperative IL-8 concentration. TXA data points (n=16) are shown orange circles and lines and Placebo data points (n=16) Robust regression lines are shown.

Journal: medRxiv

Article Title: Exploratory Randomised Trial of Tranexamic Acid to Decrease Postoperative Delirium in Adults Undergoing Lumbar Fusion: A trial stopped early

doi: 10.1101/2024.10.16.24315638

Figure Lengend Snippet: Postoperative S100B concentration vs. postoperative IL-8 concentration. TXA data points (n=16) are shown orange circles and lines and Placebo data points (n=16) Robust regression lines are shown.

Article Snippet: As a measure of neuroinflammation (astrocyte activation), plasma was analyzed for S100B protein using the Human S100B DuoSet enzyme linked immunosorbent assay (R&D Systems, Minneapolis, MN) following the manufacturer’s instructions (The lower limits of detection of each assay are reported in ).

Techniques: Concentration Assay

Maximum postoperative delirium severity vs a) number of instrumented vertebral levels and vs postoperative concentrations of b) IL-8; c) IL-10; d) TNFα; e) IL-6; and f) S100B. TXA data points are shown in purple circles and lines and Placebo data points are shown in blue circles and lines. In panel a) TXA (n=32) and Placebo (n=33). In panels b-f) TXA (n=16) and Placebo (n=16). Robust regression lines are shown.

Journal: medRxiv

Article Title: Exploratory Randomised Trial of Tranexamic Acid to Decrease Postoperative Delirium in Adults Undergoing Lumbar Fusion: A trial stopped early

doi: 10.1101/2024.10.16.24315638

Figure Lengend Snippet: Maximum postoperative delirium severity vs a) number of instrumented vertebral levels and vs postoperative concentrations of b) IL-8; c) IL-10; d) TNFα; e) IL-6; and f) S100B. TXA data points are shown in purple circles and lines and Placebo data points are shown in blue circles and lines. In panel a) TXA (n=32) and Placebo (n=33). In panels b-f) TXA (n=16) and Placebo (n=16). Robust regression lines are shown.

Article Snippet: As a measure of neuroinflammation (astrocyte activation), plasma was analyzed for S100B protein using the Human S100B DuoSet enzyme linked immunosorbent assay (R&D Systems, Minneapolis, MN) following the manufacturer’s instructions (The lower limits of detection of each assay are reported in ).

Techniques:

Postoperative S100B concentration vs. postoperative IL-8 concentration. TXA data points (n=16) are shown orange circles and lines and Placebo data points (n=16) Robust regression lines are shown.

Journal: medRxiv

Article Title: Exploratory Randomised Trial of Tranexamic Acid to Decrease Postoperative Delirium in Adults Undergoing Lumbar Fusion: A trial stopped early

doi: 10.1101/2024.10.16.24315638

Figure Lengend Snippet: Postoperative S100B concentration vs. postoperative IL-8 concentration. TXA data points (n=16) are shown orange circles and lines and Placebo data points (n=16) Robust regression lines are shown.

Article Snippet: As a measure of neuroinflammation (astrocyte activation), plasma was analyzed for S100B protein using the Human S100B DuoSet enzyme linked immunosorbent assay (R&D Systems, Minneapolis, MN) following the manufacturer’s instructions (The lower limits of detection of each assay are reported in ).

Techniques: Concentration Assay

Figure 5. BDNF, NSE, and S100B immunoreactivity in the hippocampuses and PBMCs of patients with MTLE; scale bar: 50 µm.

Journal: International journal of molecular sciences

Article Title: Concordance between the In Vivo Content of Neurospecific Proteins (BDNF, NSE, VILIP-1, S100B) in the Hippocampus and Blood in Patients with Epilepsy.

doi: 10.3390/ijms25010502

Figure Lengend Snippet: Figure 5. BDNF, NSE, and S100B immunoreactivity in the hippocampuses and PBMCs of patients with MTLE; scale bar: 50 µm.

Article Snippet: S100B levels were analyzed using enzyme-linked immunosorbent assays (ELISAs) with a DuoSet ELISA kit (DY1820-05; R&D Systems, Minneapolis, MN, USA), according to the manufacturer’s instructions.

Techniques: